Topology and organization of human Rh (rhesus) blood group-related polypeptides.
نویسندگان
چکیده
منابع مشابه
THE Rh BLOOD GROUP SYSTEM
T he Rh blood group system is one of the most polymorphic and antigenic blood group systems. It is second only to ABO in importance in blood transfusion and is well known as a primary cause of hemolytic disease of the fetus and newborn (HDFN). The principal antigen is D, and the terms Rh positive and Rh negative refer to the presence or absence of D antigen. Caucasians of European extraction ha...
متن کاملRh and LW blood group antigens
History and nomenclature The Rh system is second only to the ABO system in importance in transfusion medicine because Rh antigens, especially D, are highly immunogenic and cause hemolytic disease of the fetus and newborn (HDFN) and hemolytic transfusion reactions (HTRs). HDFN was first described by a French midwife in 1609 in a set of twins, one of whom was hydropic and stillborn, whereas the o...
متن کاملLocalization of the C termini of the Rh (rhesus) polypeptides to the cytoplasmic face of the human erythrocyte membrane.
We have raised a rabbit antiserum to a synthetic peptide corresponding to the C terminus (residues 400-416) of the Rh30A polypeptide. The rabbit antiserum reacted with the Rh30B (D30) polypeptide in addition to the Rh30A (C/c and/or E/e) polypeptide(s), indicating that these proteins share homology at their C termini. The antiserum did not react with erythrocyte membranes from an individual wit...
متن کاملThe Rh blood group system: a review
The Rh blood group system is one of the most polymorphic and immunogenic systems known in humans. In the past decade, intense investigation has yielded considerable knowledge of the molecular background of this system. The genes encoding 2 distinct Rh proteins that carry C or c together with either E or e antigens, and the D antigen, have been cloned, and the molecular bases of many of the anti...
متن کاملRh blood group of grandmother and incidence of erythroblastosis.
Ramos de Almeida, J. M., and Rosado, L. (1972). Archives of Disease in Childhood, 47, 609. Rh blood group of grandmother and incidence of erythroblastosis. Maternal red cells may cross the placental barrier and enter the fetal circulation, and this transfer may cause primary sensitization in Rh-negative girls born to Rh-positive mothers. 60 families were studied. Each family consisted of the gr...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)37388-x